LIPOSOMES AS A TARGETED DELIVERY SYSTEM OF DRUGS (REVIEW)

Liposomal targeted drug delivery makes it possible to achieve effective concentration in the target cell under various pathological conditions. The main advantage of liposomal particles is their biodegradability and immunological neutrality, which improves safety profile drugs. review provides information on composition liposomes: component membrane phospholipids, provide its strength protect from mechanical impacts. are distinguished by size number bilayer membranes, also secreted liposomes with a non?lamellar organization. selected depending purpose, including excipients that affect properties functions liposomes, rate release components, affinity for tissue, etc. considers methods obtaining features use, advantages disadvantages. creation sensitive external or internal physicochemical factors realize drugs effects, localize site action reduce severity side effects. Currently, liposome?based successfully used fields medicine – dermatology, cardiology, oncology, neurology, most active condact preclinical clinical studies treatment malignant neoplasms. Particular attention paid work Russian researchers field delivery. It shown today an open study improvement system